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Agragene Licenses Pairwise's Fulcrum® Platform to Support Cleaner Pest ControlPairwise branding against a nature-inspired green gradient
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ST. LOUIS, MO. and DURHAM, NC, June 23, 2026 — Pairwise, a global innovator in agriculture, today announced a licensing agreement with Agragene, a sustainable agricultural technology company developing biological crop pest protection, granting access to Pairwise's Fulcrum® CRISPR platform.

Agragene will integrate Fulcrum® tools into the development of its Precision-Guided Sterile Insect Technology (pgSIT), which produces sterile male insects for proactive control of pest populations, increasing yields for growers. Agragene's first product (KNOCKOUT™ SWD) targets spotted wing drosophila (SWD), an invasive fly responsible for more than $1billion annually in losses to U.S. and Canadian berry, cherry, and other soft fruit crops. Because the technology is highly species-specific, it suppresses only the target pest, leaving crops, beneficial insects such as bees and ladybugs, and the surrounding environment unaffected.  

“Growers are running out of options as pests develop resistance to conventional insecticides, and they are looking for tools that are safe, targeted, and sustainable,” said Bryan Witherbee, President and CEO of Agragene. “Our mission is to deliver cleaner pest control that supports healthier crops and a healthier planet. Access to Fulcrum® strengthens the editing technology behind our pgSIT platform and helps us move faster from field trials towards practical tools growers can use.”

“Pairwise works across all of agriculture, which means partnering with people closest to the problems,” said Dr. Tom Adams, CEO of Pairwise. “Agragene is the first to apply Fulcrum® in insect systems, and it's exactly the kind of creative use we hoped good tools would find."

The Pairwise Fulcrum® platform includes proprietary CRISPR editing tools, enzymes, and trait libraries that enable precise genetic changes. Pairwise developed and proved the platform in its own breeding programs and makes it available to partners and licensees worldwide for research and commercial purposes.

About Agragene

Agragene is a sustainable agricultural technology company based in St. Louis, Missouri, developing biological crop pest protection products. Using Precision-Guided Sterile Insect Technology (pgSIT), a CRISPR-based platform, Agragene provides sterile male insects to reduce and control pest populations while reducing reliance on traditional insecticides. Founded in 2017, the company is pursuing commercial product launch in the U.S. and a licensing strategy worldwide. For more information, visit www.agragene.com

About Pairwise

Pairwise is agriculture's gene editing powerhouse, building a healthier world through partnership and plant innovation. Co-founded by early pioneers of CRISPR, Pairwise's Fulcrum® Platform accelerates the development of climate-resilient, nutritious, and sustainable crops. As a trusted partner to global industry leaders and nonprofit institutions, Pairwise helps breeders move faster while transforming food and agriculture for farmers, consumers, and the planet. Founded in 2017 and based in Durham, NC, Pairwise is committed to delivering innovation that makes food easier to grow and better to eat. For more information, visit www.pairwise.com.

Agreement marks the first application of Fulcrum® technology in insects, supporting proactive & effective pest control
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Hudson River Biotechnology and Pairwise Sign Fulcrum® Licensing AgreementPairwise branding against a nature-inspired green gradient
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Wageningen, Netherlands and Durham, N.C. — May 26, 2026 — Hudson River Biotechnology (Hudson River) and Pairwise have signed a licensing agreement giving Hudson River access to the Fulcrum® plant gene editing platform. Hudson River will integrate Fulcrum® tools into its editing services, which it offers to crop improvement customers working in vegetable, soft fruit, and other species.

Hudson River is an independent plant biotechnology company based in the Netherlands, specializing in genome editing, plant regeneration and trait development. A Fulcrum® license gives Hudson River access to a broader set of editing tools, complementing their established BioMaas workflow.

"Our customers increasingly recognize genome editing as a crucial part of their breeding tools and come to us for our ability to apply this technology in a transgene-free manner directly in elite lines and flexible partnership models,” said Lotte Westerhof, CSO of Hudson River. “Fulcrum® expands the editing toolbox we can offer, enabling us to support a broader range of applications and opportunities for our customers."

"Partnerships like this one are how Fulcrum® reaches more breeders and more crops," said Ian Miller, COO of Pairwise. "We’re excited to work with Hudson River extending our platform for specialty crops where their customers are already active — accelerating the delivery of beneficial crops to agriculture."

Fulcrum® is Pairwise's integrated plant gene editing platform, encompassing gene editing tools, enzymes, and trait libraries that enable precise changes across a wide range of crop species. The platform is developed and proven in Pairwise's own breeding programs and is made available to partners and licensees worldwide.

About Hudson River Biotechnology

Hudson River Biotechnology is an independent plant biotechnology company focused on advancing crop improvement for a more resilient and sustainable bioeconomy. Combining expertise in genome editing, plant regeneration, and trait development, Hudson River enables breeding companies to integrate next-generation breeding technologies into commercial crop development. For more information, email info@hrb.bio.

About Pairwise

Pairwise is agriculture's gene editing powerhouse, building a healthier world through partnership and plant innovation. Co-founded by CRISPR pioneers, our Fulcrum® Platform accelerates the development of climate-resilient, nutritious, and sustainable crops. As trusted partners to global industry leaders and nonprofit institutions, we help breeders move faster while transforming food and agriculture for farmers, consumers, and the planet. Founded in 2017 and based in Durham, NC, Pairwise is committed to delivering innovations that make food easier to grow and better to eat. For more information, visit www.pairwise.com.

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Hudson River expands their plant genome editing offering with access to Pairwise's plant gene editing platform
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Sun World International and Pairwise Launch Strategic Partnership to Develop a Holy Grail of Produce – the Pitless Cherry Pairwise branding against a nature-inspired green gradient
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Sun World International and Pairwise today announced the formation of a joint venture to collaborate in specialty fruit, beginning with the development of a pitless cherry.  Sun World will have exclusive commercial rights to these genetics as they seek a first-to-market position in high-quality pitless cherries. The partnership leverages Sun World’s fruit breeding and licensing expertise with Pairwise’s Fulcrum® platform. As part of the agreement, Sun World will make strategic investments to fund development.

In addition to maximizing yield and mitigating against climate change, one of Sun World’s north stars is providing a demonstrably superior consumer eating experience in every way including optimizing convenience. Sun World has a rich heritage of pioneering convenience-focused innovations, beginning with the SUPERIOR SEEDLESS® table grape in 1972, the Sun World seedless watermelon in 1988, countless contributions to their seedless table grape range over three decades, the commercialization of seedlessness in easy-peel mandarins, and the introduction of the seedless lemon.

“Our focus has long been on offering truly differentiated genetics to our growers with exceptional new traits, flavors, texture and convenience,” said Bernardo Calvo, Sun World’s CEO. “Developing a high-quality pitless cherry is a natural innovation evolution for us and in Pairwise, we’ve found an extraordinary partner already well down this quite complex path.”

Pairwise, which has developed the world's first seedless blackberry, brings an unmatched platform that accelerates the development of in-demand crop traits. Traditional breeding involves a lengthy process, but this approach creates a faster path to fruits that consumers will enjoy while providing growers with crops that offer greater sustainability, improved disease resistance, and higher yields.

"This is a segment of agriculture where there's tremendous opportunity to bring meaningful innovation," said Dr. Tom Adams, CEO of Pairwise. "Sun World has built one of the most successful commercial pipelines in fruit genetics.  Combining that expertise with the precision and efficiency of Pairwise’s Fulcrum platform allows us to address unmet consumer and grower needs in a way that hasn't been possible before."

Pairwise will lead the R&D effort, while Sun World contributes its germplasm, breeding infrastructure, and commercial market access. The joint venture is already advancing development work and may explore additional strategic partnerships. In addition to its focus on consumer traits, the collaboration aligns with broader industry efforts to use advanced plant breeding to support sustainable agriculture, reduce waste, and create higher-value outcomes for both consumers and producers.

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About Sun World  

Sun World International is a global fruit variety development and licensing company, propelled by emerging technologies, and rooted since its inception in the principles of sustainability. Sun World pioneered seedless grape varietal development and formalized their fruit genetics program three decades ago. Sun World specializes in table grapes, mandarins, mangoes, stone fruit and cherries and is part of the Bridgepoint Group of private equity investors. www.sun-world.com.  

About Pairwise

Pairwise is agriculture’s gene editing powerhouse, building a healthier world through partnership and plant innovation. Co-founded by the inventors of CRISPR, our Fulcrum® Platform accelerates the development of climate-resilient, nutritious, and sustainable crops. As trusted partners to global industry leaders and nonprofit institutions, we help breeders move faster while transforming food and agriculture for farmers, consumers, and the planet. Founded in 2017 and based in Durham, NC, Pairwise is committed to delivering innovation that makes food easier to grow and better to eat. For more information, visit www.pairwise.com.

Joint Venture Combines Advanced Plant Breeding Technology with Global Fruit Expertise to Deliver Consumer-Desired Traits
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