Pairwise is agriculture's plant CRISPR powerhouse

Pairwise, a company pioneering genetics-based innovation in food and agriculture, has developed the world’s first seedless blackberry. Created using the company’s proprietary Fulcrum™ Platform, a complete suite of novel tools for CRISPR application in plants, this is the first time seedlessness has been achieved in any caneberry.

“We are thrilled to share this breakthrough achievement from our talented R&D team. Pairwise scientists have used their deep knowledge of plant genetics, broad suite of CRISPR tools, and multiplex editing techniques to eliminate the hard pits in berry fruit, creating soft, small seeds like those found in grapes and watermelon that are commonly labeled as seedless,” said Ryan Bartlett, Pairwise Chief Technology Officer. “The result is the first seedless blackberry in the world. We expect that this trait will not only transform the blackberry market, but it also lays the groundwork for accelerated progress in removing seeds and pits in many other fruits such as cherries.”

Recent innovations in produce have been rapidly adopted due to the significant benefits they provide consumers, such as improved flavor, consistency, and convenience.  

“The berry variety we edited is consistently sweet year-round and holds up well during shipment; now, consumers will have the option to choose a nutritious blackberry without seeds that also reliably delivers great flavor and quality,” said Haven Baker, Pairwise Co-Founder and Chief Business Officer. “Blackberries are a snackable fruit with significant health benefits; however, data indicates that more than 30% of berry buyers do not like the seeds, and many more do not even buy the fruit because of the seeds.”

In addition to creating the first seedless caneberry, Pairwise has successfully edited the same variety to eliminate thorns and create a more compact plant that delivers benefits for harvesters, growers, and the environment. The thornless and compact traits enable more efficient fruit harvesting and improved productivity and profitability for growers. The new compact trait means the plants are smaller and can be planted at a higher density per acre.

With the precision of CRISPR, we’re able to develop these thornless and compact traits without sacrificing consistency in flavor and quality for consumers,” said Baker. “We’re excited to advance these berries into the next phase of product development, including outdoor field trials, as we work toward scaling up and making them available to the public in a few years.”

“A key challenge in our food system is helping people eat more high-quality, healthy foods. As part of our drive to increase the consumption of fruit and vegetables, we’re working to provide consumers with new, highly nutritious food options with improved flavor and convenience,” said Tom Adams, Pairwise Co-Founder and CEO. “With a deep understanding of the plant genome, an accurate, efficient, and scalable process, and streamlined pathway to commercialization, we are not only creating new products with our proprietary CRISPR technology, we are creating a new era of innovation in agriculture.”

Learn more about Pairwise and its proven Fulcrum Platform here.

About Pairwise:

Pairwise is pioneering the application of CRISPR technology in food and agriculture. The company brings together leaders in agriculture, technology, and consumer foods to harness the transformative potential of new genomics technologies to create innovative new products. Pairwise is working to develop new varieties of crops, and to partner with organizations that seek to deliver innovation across the plant-based economy. Backed by industry leading investors Deerfield, Aliment Capital, Leaps by Bayer, and Temasek, Pairwise raised $90 million in a successful series B funding round in February 2021, bringing total fundraising to $115 million. The company was founded by Chief Executive Officer Tom Adams and Chief Business Officer Haven Baker, with scientific co-founders J. Keith Joung, Lead Translator at Arena BioWorks; David Liu, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; and Feng Zhang, McGovern Investigator and a professor at MIT. For more information, visit Pairwise.com, and learn more about the differentiating Pairwise Fulcrum™ Platform here.

Pairwise, a technology company pioneering gene editing to improve plant breeding in specialty and commodity crops, has closed a $40M Series C funding round led by Deerfield Management. Multiple returning investors, including Aliment Capital and Leaps by Bayer, are joined by new investor and global ag technology leader Corteva, Inc. (NYSE: CTVA), through its Corteva Catalyst platform, further signaling the promise and anticipated benefits of gene editing in agricultural applications.

Delivering Transformative Improvements in Food and Agriculture

Investments from this funding round will be used to scale Pairwise’s innovative product pipeline, including seedless berries and pitless cherries, as well as advance its industry-leading Fulcrum™ Platform. Pairwise’s new seedless blackberry variety, announced in June, will deliver an improved eating experience for consumers and, in concert with compact architecture and thornless traits, bring added benefits to farm workers, growers, and the environment as well.

“We started Pairwise in the early days of CRISPR to accelerate innovation across agriculture, enabling the cultivation of crops that are more adaptive to climate change, and more nutritious and convenient for consumers, all while bolstering grower economics,” said Tom Adams, Pairwise Co-Founder and CEO. “This new investment will enable us to expand the impact of our proprietary Fulcrum Platform as we continue to lead this transformation with our proven ability to deliver novel solutions that address the most pressing challenges in agriculture today.”

“Using their novel tools, Pairwise has delivered game-changing edits in plant varieties across consumer and big-acre crops in just a few short years,” said Cam Wheeler, Partner at Deerfield Management and Pairwise Chairman of the Board. “We believe that the precision, speed, and safety of gene editing is poised to transform agriculture, and our ongoing investment reflects our confidence in Pairwise as the clear leader in this space.”

Corteva Chief Technology and Digital Officer Sam Eathington said, “We view gene editing as a critical solution to drive climate resilience across agriculture and global food systems. Pairwise is an obvious choice for our investment to help accelerate innovation through gene editing in fruit, vegetables, and specialty crops. And as leaders in gene editing ourselves, Corteva’s ultimate aim is to work with Pairwise to unlock the impact of this technology to help solve climate challenges and produce the food, fiber and fuel required to meet the needs of a growing global population.”

In parallel to Corteva’s equity investment in Pairwise, the two companies have entered into a five-year joint venture collaboration that will focus on accelerating the pace of gene edited technologies and developing improved products that are more resilient to future climate conditions.

Corteva’s investment in Pairwise is being made through Corteva Catalyst, the company’s new investment and partnership platform launched to boost agricultural R&D and sustainable food production innovations.  

Trailblazing a New Era in Accelerated Innovation

Pairwise was founded by proven business leaders, preeminent experts, and inventors of early gene-editing technologies. Using industry-leading knowledge of plant genetics, a broad suite of CRISPR tools, and high-impact editing techniques like multiplexing, Pairwise has delivered multiple products with differentiated plant genetics across significant crops, including corn, soy, wheat, canola, leafy greens, blackberries, and more. As one of the only companies in this space to launch commercially viable products to date, Pairwise introduced the first CRISPR food to North America – a blend of superfood mustard greens that eat like lettuce, edited to dial down the wasabi-like pungency for people looking for healthier salad options than what are available in the marketplace today.  After laying the important commercial groundwork, the company entered into an exclusive product licensing agreement with Bayer to further develop and sell 10 varieties of Pairwise-edited greens at scale, and to develop and breed for new varieties with the technology. Additionally, after delivering 27 novel traits to Bayer’s pipeline under an initial five-year partnership, the two companies entered a second, multi-year collaboration to focus on developing a gene-edited version of short-stature corn to offer farmers better protection for their crops given improved sustainability in high winds and challenging weather conditions, better access during the season, and higher yields.

The Pairwise Fulcrum™ Platform includes company-developed gene editing tools for cutting, base editing, and templated editing – a toolbox that enables not only turning a characteristic on or off, like removing a plant’s thorns to enable easier fruit harvesting, but also “tuning” it – like a dimmer switch to dial a trait up or down, such as creating a new type of corn with up to 20% more kernel rows. Using Pairwise’s novel editing tools, scientists can precisely tailor a wide range of genetic variation to develop new, distinctive plant varieties much faster and more effectively than through conventional breeding. In concert with its industry-leading tools, Pairwise’s intellectual property enables a straightforward path to product commercialization.

"Our technology licensing agreements provide secured IP and increase shareholder value. And our proprietary suite of technologies – our Fulcrum Platform – is enabling us to unlock transformative improvements in global agriculture,” added Adams. “Our product-development partnerships with global agriculture leaders, Corteva and Bayer, underscored by investments from both Corteva Catalyst and Leaps by Bayer, are an incredible validation of our technology and an important signal that gene editing will play a major role in improving agriculture innovation moving forward.”

Institutions interested in learning about Pairwise investment or licensing opportunities may contact the company at www.Pairwise.com.

About Pairwise:

Pairwise is pioneering the application of gene editing technology in food and agriculture. The company brings together leaders in agriculture and tech to harness transformative genomic technologies to create innovative new products that benefit society. Pairwise is working to develop new varieties of fruits, vegetables, and large-acre crops, and to partner with organizations that seek to deliver innovation across the plant-based economy. Backed by industry leading investors Deerfield, Aliment Capital, Leaps by Bayer, Temasek, and Corteva Catalyst, Pairwise raised $40 million in a successful funding round in September 2024, bringing total fundraising to $155 million. The company was co-founded by the company’s CEO Dr. Tom Adams and agriculture innovator Dr. Haven Baker, with scientific co-founders J. Keith Joung, Lead Translator at Arena BioWorks; David Liu, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; and Feng Zhang, McGovern Investigator and a professor at MIT. For more information, visit Pairwise.com, and learn more about the differentiating Pairwise Fulcrum™ Platform here.

The International Institute of Tropical Agriculture (IITA), in partnership with Pairwise, a US-based technology company pioneering the application of gene editing in food and agriculture, is delighted to announce a grant of US$ 3,874,356 from the Bill & Melinda Gates Foundation. This grant will support the “Yam Optimized Architecture through Gene Editing (YOAGE)” project, an innovative project aimed at delivering novel genetic variation to yam (Dioscorea spp.) that improves plant architecture. The project goal is to reduce labor and environmental impact associated with traditional plant staking while also enabling mechanized farming in Nigeria, where yam is an important staple food crop.

The 4-year YOAGE project will focus on developing yam varieties with optimized growth characteristics, improving cultivation practices, and boosting productivity and profitability while collaborating with various stakeholders, including local farmers, agricultural experts, and policymakers. Yam is the second most important root and tuber crop in sub-Saharan Africa after cassava, with a production of about 75 million metric tons (FAO, 2021) and provides about 200 kilocalories daily to over 400 million people in the low-income and food-deficit countries of the tropics. Africa produces over 97% of the global yams, with Nigeria alone accounting for about 66% of the world’s total (FAO, 2021). In West Africa, particularly in Nigeria, yam is not only a staple crop but also plays a central role as a traditional flagship crop deeply intertwined with societal norms, fulfilling various social and religious functions.

Despite this importance, yam cultivation faces several challenges, such as high costs of planting materials and labor, declining soil fertility, low-yielding varieties that require staking, and increased pest and disease pressures due to intensified farming. While conventional breeding has improved yam varieties for pest resistance, adaptability, and quality, it has made limited progress in optimizing plant architecture for mechanized farming. The YOAGE project will leverage advanced gene editing tools to overcome these challenges and support global food security, particularly in the face of climate change, resource limitations, and shifting consumer demands.

Leena Tripathi, IITA Eastern Africa Hub Director, Biotechnology Program Lead, and YOAGE Principal Investigator, said: “Receiving this grant from the Gates Foundation marks a pivotal advancement in transforming yam production through innovative gene editing technologies. By developing improved bushy-types of yam varieties, we aim to reduce labor demands, enhance farming efficiency, and boost sustainability. Ultimately, our goal is to elevate farmers’ livelihoods and strengthen food security.”

The YOAGE project aims to develop these varieties by identifying the genes controlling plant growth, optimizing gene editing to develop semi-dwarf varieties, and analyzing the impacts of these changes on labor and gender dynamics. By addressing the technical and environmental challenges of yam production, the project is expected to significantly improve productivity and farmers’ income, contributing to the global goal of sustainable agriculture and food security.

The Gates Foundation selected IITA and Pairwise for the grant because of their proven records in agricultural innovations and community engagements in the region. IITA is a global center of excellence for yam breeding and a genetic improvement source of new and improved yam genotypes for major yam growers in Africa. Also, it has a long tradition and experience in the breeding and genetics of yam, a well-established yam breeding network that connects several national programs from major yam-growing areas in Africa.

Pairwise is pioneering the application of gene editing technology in food and agriculture through its Fulcrum™ Platform, the most extensively developed and validated toolbox for CRISPR application in plants. As one of the first companies in the world to commercialize gene-edited consumer food and agricultural products, Pairwise brings together leaders in agriculture, technology, and consumer foods to harness the transformative potential of new genomics technologies to create innovative new products.

“The Gates Foundation sees gene editing as an opportunity to more rapidly advance important crops like yam, following a path established through a long history of crop breeding. Through gene editing, we can keep all the favorable characteristics of adapted crops, such as nutrition and climate resilience, while removing characteristics like vining in yams that limit a crop’s potential. By partnering IITA with Pairwise, we have brought together top scientists to tackle this important challenge and drive adoption of improved varieties for smallholder farmers.” explained Dr Nicolas Bate, the Senior Program Officer at Bill & Melinda Gates Foundation.

Pairwise Director of Trait Strategy and Testing, Dr Shai Lawit, added: “Gene editing offers a revolutionary approach to solving global challenges in agriculture. Through important public-private initiatives like this one with IITA, the Bill & Melinda Gates Foundation, and Pairwise, we are not only improving crop production; we’re also empowering smallholder farmers, reducing environmental impacts, and advancing food security to narrow the global nutritional deficit, which is especially prevalent in developing countries.”

Through this combined work, the YOAGE project will demonstrate the importance of public-private partnerships in unlocking the benefits of gene editing in Nigeria and Africa at large.

About IITA

The International Institute of Tropical Agriculture (IITA) is a not-for-profit institution that generates agricultural innovations to address Africa’s most pressing challenges of hunger, malnutrition, poverty, and natural resource degradation. Working with various partners across sub-Saharan Africa, IITA improves livelihoods, enhances food and nutrition security, increases employment, and preserves natural resource integrity. IITA is a member of CGIAR, a global agriculture research partnership for a food and nutrition secure future.

About Pairwise:

Pairwise is pioneering the application of gene editing technology in food and agriculture. The company brings together leaders in agriculture and tech to harness transformative genomic technologies to create innovative new products that benefit society. Pairwise is working to develop new varieties of fruits, vegetables, and large-acre crops, and to partner with organizations that seek to deliver innovation across the plant-based economy. Backed by industry leading investors Deerfield, Aliment Capital, Leaps by Bayer, Temasek, and Corteva Catalyst, Pairwise raised $40 million in a successful funding round in September 2024, bringing total fundraising to $155 million. The company was co-founded by the company’s CEO Dr. Tom Adams and agriculture innovator Dr. Haven Baker, with scientific co-founders J. Keith Joung, Lead Translator at Arena BioWorks; David Liu, Director of the Merkin Institute of Transformative Technologies in Healthcare, and Vice-Chair of the Faculty at the Broad Institute of Harvard and MIT; and Feng Zhang, McGovern Investigator and a professor at MIT. For more information, visit Pairwise.com, and learn more about the differentiating Pairwise Fulcrum™ Platform here.